Mindfulness-Based Stress Reduction (MBSR) is a program that incorporates mindfulness meditation and yoga to help people cope with stress, anxiety, and depression. It was developed by Dr. Jon Kabat-Zinn at the University of Massachusetts Medical Center in the 1970s. The program teaches participants to cultivate mindfulness, which involves paying attention to the present moment without judgment. MBSR has been widely researched and has been found to be effective in helping people manage various forms of psychological and physical distress.